Head/Director of in Vivo Pharmacology/R&D 体内药理部门负责人/研发总监
2 months ago
Job responsibilities:
- Lead the department/team to participate in the comprehensive in vivo/early in vivo research and development project at all stages of drug development in preclinical stage, and help deliver high-quality drug candidates that can be used in preclinical research;
- Cooperated and communicated with the new drug research and development project team and in vivo pharmacology-related CRO enterprises to carry out tolerance, pharmacodynamic evaluation and preliminary pharmacological studies of drug candidates using relevant in vivo animal models;
- Designed in vivo efficacy experiment scheme, reviewed data, made statistical analysis, found problems and proposed solutions;
Qualifications:
- PhD degree, major in pharmacology, animal medicine, immunology or biomedicine, with more than 10 years of research and development related work experience in the biomedical industry;
- Proficient in the establishment methods of relevant animal models (including CDX, PDX, Syngeneic and humanized models), application scenarios and efficacy evaluation methods of anti-tumor/non-tumor drugs;
- Familiar with the experimental techniques of pharmacokinetics, pharmacology and toxicology research, including in vivo experiments and the analysis and processing of experimental data;
- Experience in coordinating and managing CRO organizations;
- Strong innovative spirit and scientific and rigorous logical thinking ability, able to analyze and solve problems independently;
- Good English reading and writing skills, able to independently consult literature, write relevant professional reports and declaration materials;
- The specific job rank will be determined according to the comprehensive qualifications of the candidate.
岗位职责：
1. 领导部门/团队参与药物研发临床前各个阶段的体内/早期体内研发综合项目，助力交付可用于临床前研究的优质候选药物；
2. 与新药研发项目组及体内药理相关CRO企业协作沟通，利用相关体内动物模型对候选药物开展耐受性、药效学评价和初步药理学研究等；
3. 设计体内药效实验方案、审核数据、统计分析，发现问题并主动提出解决方案；
任职资格：
1. 博士学历，药理学、动物医学、免疫学或生物医学等相关专业，具有10年以上生物医药行业的研发相关工作经验；
2. 熟练掌握相关动物模型（包括CDX、PDX、Syngeneic及人源化模型）建立方法，应用场景及抗肿瘤/非肿瘤药物的药效评价的方法；
3. 熟悉药代、药理，毒理研究的实验技术，包括体内实验，实验数据的分析处理；
4. 具有协调和管理CRO组织工作的经验；
5. 较强的创新精神以及科学严谨的逻辑思维能力，能够独立的分析和解决问题；
6. 良好的英语阅读和写作能力，能独立查阅文献资料、撰写相关专业报告及申报资料；
7. 具体岗位职级将根据候选人综合资质确定。
欢迎海外人才考虑回国发展，工作地点：中国上海
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