Senior Scientist
4 weeks ago
Senior Scientist (Oligonucleotide Therapeutics) We are seeking a highly skilled and motivated Senior Scientist to join our group dedicated to the drug discovery and technology development specifically in oligonucleotide therapeutics, such as antisense oligonucleotides and siRNAs. You will design and screen oligonucleotide candidates as well as carry out research on technology development to improve chemistry and delivery of nucleic acid therapeutics (siRNA/ASO). Typical Day Might Include Maintaining and culturing cell lines and primary cells, as well as generating stable cell lines. Optimizing assays to test oligonucleotide drug candidates such as siRNAs/ASOs using both cell-based activity assays (cell migration, viability, microscopy, flow cytometry, etc.) and RNA based activity assays (RT-qPCR, RISC loading, RNaseH cleavage). Running and analyzing off‑target profiles, proposing optimizations, and designing PK/PD, stability, and metabolic profiling assays. Carrying out routine molecular biology and biochemistry tasks including PCR, western blot, etc. Optimizing and implementing protocols to test novel delivery techniques for oligonucleotides based on antibodies, peptides and other conjugates. Working on developing tissue specific delivery platforms for nucleic acid therapeutics. Working closely with the synthetic chemistry group to optimize chemistry of nucleic acid drug candidates. Qualifications Ph.D. and at least 2+ years of relevant experience in the siRNA/gene therapy space. Experience working with siRNA/ASOs and an in-depth knowledge in gene transcription and protein translation, RNA splicing, and gene expression regulation. Experience in cell-based screening assays, such as ELISA, luciferase, fluorescence and Western blotting is required. Experience in flow cytometry and bDNA assays are highly preferred. Strong cell culture and RT-qPCR skills. Experience working in vivo and genotyping is a plus. Generating stable cell lines with various viral vectors (retrovirus, lentivirus, adeno‑associated virus, etc.) is strongly preferred. Experience in bioconjugation, working with chromatography systems for biomolecule purifications is advantageous. Salary Range (annually) $108,300.00 - $176,700.00 Equal Opportunity Employer Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. #J-18808-Ljbffr
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Senior Associate Scientist
1 week ago
Village of Tarrytown, United States Regeneron Full timeJoin to apply for the Senior Associate Scientist - Keloid & Fibrosis role at RegeneronJoin to apply for the Senior Associate Scientist - Keloid & Fibrosis role at RegeneronGet AI-powered advice on this job and more exclusive features.We are seeking a highly motivated Senior Associate Scientist to join the Keloid and Fibrosis Team in Regeneron’s...
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Senior Scientist: Motor Neuron Diseases
3 weeks ago
Village of Tarrytown, United States Proclinical Group Full timeSenior Scientist: Motor Neuron Diseases - Contract - Tarrytown NY Are you looking to make an impact with your innovation? Proclinical is working with a well-established pharmaceutical company to recruit for a Senior Scientist! This position includes completing basic research studies which are designed to understand the biology behind various...
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Village of Tarrytown, United States Regeneron Full timeSenior Principal Scientist, AI/ML Antibody Design & EngineeringJoin to apply for the Senior Principal Scientist, AI/ML Antibody Design & Engineering role at RegeneronSenior Principal Scientist, AI/ML Antibody Design & EngineeringJoin to apply for the Senior Principal Scientist, AI/ML Antibody Design & Engineering role at RegeneronGet AI-powered advice on...
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Senior Associate Scientist- Flow Cytometry
2 weeks ago
Village of Tarrytown, United States Regeneron Full timeSenior Associate Scientist - Flow Cytometry Join Regeneron as a Senior Associate Scientist – Flow Cytometry in our Protein Expression Sciences team. You will operate and maintain high‑speed cell sorters and analyzers, provide protocol design and data analysis, support scientific staff, train users, and help maintain the core facility. Responsibilities...
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Senior Scientist, Analytical Chemistry
2 weeks ago
Village of Tarrytown, United States Regeneron Full timeSenior Scientist, Analytical Chemistry Regeneron Pharmaceutical’s Analytical Chemistry Group is seeking a highly motivated Senior Scientist to join our group. Our group applies an understanding of various LC‑MS platforms and applications to solve analytical challenges. This Senior Scientist will work on LC‑MS technology and method development to...
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Senior Flow Cytometry Scientist: Instrumentation
2 weeks ago
Village of Tarrytown, United States Regeneron Full timeA leading biotechnology firm in Tarrytown, NY is seeking a Senior Associate Scientist in Flow Cytometry to operate high-speed cell sorters and provide protocol design and data analysis. The ideal candidate has a Bachelor’s degree and 3–4 years of experience in the field, with strong troubleshooting and communication skills. This full-time role offers a...
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Village of Tarrytown, United States Regeneron Full timeA biotechnology company in New York is seeking a Senior Scientist in Analytical Chemistry to lead the evaluation and characterization of biotherapeutics. The successful candidate will apply their mass spectrometry expertise, have a strong background in analytical challenges, and demonstrate excellent problem-solving and communication skills. This full-time...
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Village of Tarrytown, United States Regeneron Full timeSenior Manager, Clinical Scientist, Genetics Medicine Join Regeneron to apply for the Senior Manager, Clinical Scientist, Genetics Medicine role. We are seeking a qualified scientist with training in the pharmaceutical/biotechnology sector, or academic or clinical setting, to work closely with the supervisor and other cross‑functional team members,...
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Principal Scientist- Infectious Disease
1 week ago
Village of Tarrytown, United States Regeneron Full timeJoin to apply for the Principal Scientist- Infectious Disease role at RegeneronJoin to apply for the Principal Scientist- Infectious Disease role at RegeneronWe are seeking a highly skilled, motivated, and innovative Principal Scientist to lead the development of antiviral immunological therapies. In this role, you will independently lead research projects,...
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Senior Scientist, Analytical Chemistry
3 weeks ago
Village of Tarrytown, United States Regeneron Full timeSenior Scientist, Analytical Chemistry (LC-MS) Regeneron Pharmaceutical's Analytical Chemistry Group, located in Tarrytown, NY, is seeking an energetic Sr. Scientist. In this exciting role, you will work in a state‑of‑the‑art mass spectrometry lab and provide analytical and biochemical characterization of therapeutic protein drug candidates to support...
