Executive Director, PDM Operation and Portfolio Management

6 days ago

Redwood City, United States REVOLUTION Medicines Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Playing a leadership role within Pharmaceutical Development and Manufacturing (PDM) organization, the position will be responsible for leading PDM Operation and Portfolio Management function enabling cross-functional business operation needs including but not limited to strategic sourcing and supplier management, portfolio management, and operation excellence. The individual will also play a critical role in, and participate in, the overall CMC strategy planning and execution.

  • Lead global sourcing strategy development and execution to ensure appropriate and robust supply chain to support RVMD pipeline development and commercialization.
  • Lead the efforts to assess/identify potential suppliers with adequate risks and benefits assessment.
  • Provide business operational oversight for the external R&D and manufacturing activities.
  • Lead business review meetings with collective feedback across PDM functions on the overall performance of the CDMOs and CTLs to ensure operational excellence.
  • Establish scalable and robust PDM Portfolio Management systems, structures, and cultures while driving operational advancement and excellence.
  • Collaborate with drug substance (DS), analytical development & QC (ADQC), drug product (DP), supply chain (SC), CMC PM, CMC regulatory and quality (QA) to ensure overall CMC goals are met.
  • Travel to CDMOs for vendor assessment and qualification, as well as supplier oversight as needed.
Required Skills, Experience, and Education:
  • Bachelor's in science.
  • 18 + years of experience in the pharmaceutical/biotech industry with a sound track record of manufacturing operation, strategic sourcing and supplier management, operational excellence, and organizational leadership, with end-to-end development and manufacturing experience of small molecules.
  • Proven track record of strategic leadership and management with at least 8 years in the leadership role.
  • Demonstrated strong cross-functional team leadership and people management
  • Good understanding and working experience in drug development and manufacturing with respect to GMP, quality systems, ICH guidelines, FDA, EMA, and associated regulatory requirements.
  • Working experience with management and oversight of the development and manufacturing activities at CDMOs.
  • Strong problem-solving skills with strategic and sound technically driven decision-making ability.
  • Effective written and verbal communication skills and interpersonal skills.
  • Innovative team player with high energy for our dynamic company environment.
Preferred Skills:
  • BS, MS, or PhD in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field.

The base salary range for this full-time position is $253,000 to $305,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

#LI-Hybrid #LI-CT1

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