Scientist Consultant, Antibody Discovery

1 week ago

san francisco, United States Net2Source Inc. Full time

Job Description:

Job Description: Scientist Consultant, Antibody Discovery

Location: South San Francisco, CA 94080

Duration: 12+ Months (Extendable)

Pay Rate: $87.00/hr on W2


Qualifications:

PhD in Biochemistry, Biomedical/Chemical Engineering, Immunology, or related field with minimum of 2 years of post-graduate experience (preferably in industry), MS with 8+ years of research experience, BS with 10+ years of research experience in antibody or protein engineering


• Significant experience in antibody discovery and protein engineering by using single B cell cloning, hybridoma, or phage/yeast display techniques

• Strong background in molecular biology, antibody and protein expression, and biophysical characterization of recombinant antibodies and proteins

• Demonstrated experience in working collaboratively across various scientific disciplines and other parts of the organization to meet end goals

• Highly motivated individual with exceptionally good organizational skills, and attention to details

• Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines

• Excellent written and verbal communication skills

• Strong interpersonal skills


ADDITIONAL PREFERENCES

• Experience in single domain antibodies, multi-specific antibody engineering, Fc engineering, antibody drug conjugates, naïve phage or yeast display library design

• Experience in NGS analysis for antibody discovery and engineering

• Significant contributions to successful biologics drug discovery programs in biotech/biopharma industry


Responsibilities:

Design strategies and execute antibody discovery campaigns for therapeutic and reagent antibodies using phage display

• Generate antibody fragment libraries for antibody discovery and engineering, perform HT binding screens (ELISA and multi-plex flow cytometry) and sequence analysis to generate hits

• Rank-order clones by affinity, in vitro potency, and early developability assessment

• Execute sequence optimization of lead antibodies to improve developability and binding affinity

• Design and clone constructs for mAbs, bispecific, and multi-specific antibodies for recombinant antibody production

• Support NGS-based antibody discovery workflow

• Present data and updates to management and project teams

• Follow good documentation practice including maintaining good record keeping in Electronic Notebooks

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