Integrated Resources, Inc

4 days ago

lexington, United States Integrated Resources, Inc ( IRI ) Full time

Title: Senior Research Associate

Location: Lexington, MA

Duration: 12 months+


Note from Hiring Manager:

- No in vivo and human primary cell culture experience

- Not be able to answer several technical questions

- Overqualified

- Not enough experience with human primary cell culture


Focused on the in- vitro work

SiRNA/RNAi screening work

Bachelors/Masters. Prefers Masters

PhD will be over qualified

In vitro Cell culture required

In vivo is not required but might be good to have

1yr contract with possible extension

Organoid exp is preferred not required

Do not want to see overqualified candidates

primary human adipocytes and hepatocytes culture will be a deal breaker


MANAGER MUST HAVES:

1. Cell culture experience and basic cell biology methodologies such as transfection

2. Molecular biology techniques such as RNA extraction and RT-qPCR

3. Vitro model systems including organoids and other 3D culture systems is highly preferred


Purpose:

  • To provide technical laboratory research effort in support of multiple projects focused on expedited evaluation and the clinical translation of therapies.


Essential Functions:

  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR
  • Analyze data and present the results in group meetings
  • Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed
  • Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs
  • Review literature and provide insights to research directions, while predominantly making hands-on contributions to the research


Qualifications:

  • Masters in Cell and Molecular Biology or Pharmaceutical Sciences
  • 0-4 years of relevant drug discovery laboratory experience in industrial or academic environment is preferred
  • Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR)
  • Experience with primary human adipocytes and hepatocytes culture is preferred
  • Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred
  • Experience with RNAi and in vitro screening is preferred
  • Candidate must have strong oral and written communication skills, strong work ethics and demonstrated to be an effective contributor to group projects in a team-oriented environment
  • The ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected

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