Current jobs related to Sr Scientist/ Principal Investigator- Oligonucleotide Bioanalysis - Saint Louis - RPM ReSearch
-
Saint Louis, United States RPM ReSearch Full timeJob DescriptionJob DescriptionJob DescriptionPosition TitleSenior Scientist/ Principal Investigator - Bioanalysis DMPK BiotransformationWe are looking for an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a...
-
Associate Principal Investigator
4 months ago
Saint Louis, United States RPM ReSearch Full timeJob DescriptionJob DescriptionJob DescriptionPosition TitleAssociate Principal Scientist - Bioanalysis We are looking for an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a collaborative culture and mutual...
-
Senior Principal Clinical Scientist
3 days ago
Saint Paul, Minnesota, United States Abbott Laboratories Full timeAbout the RoleAbbott Laboratories is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals, and branded generic medicines.We are seeking a highly skilled Senior...
-
Senior Principal Clinical Scientist
2 days ago
Saint Paul, Minnesota, United States Abbott Laboratories Full timeAbout Abbott LaboratoriesAbbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals, and branded generic medicines.Our MissionOur mission is to restore health and...
-
Principal Scientist, Co-Drying
1 month ago
St. Louis, United States CPS, Inc. (Food & Beverage Division) Full timePrincipal Scientist, Co-Drying & Dry BlendingThe duties and responsibilities of the Principal Scientist will include the following:Research dairy science, food science and equipment for the purpose of innovating new technologies and the development of intellectual property (IP) for the companyDevelop new wet and dry dairy systems, dairy flavors, dairy...
-
Sr. Manager, Quality Validation
3 days ago
Saint Louis, United States EPM Scientific Full timeJob DescriptionJob DescriptionTitle: Sr. Manager, ValidationLocation: St. Louis, MO (Can provide relocation)A leading pharmaceutical company is seeking a validation expert to lead their site's validation program. The Senior Manager will be responsible for leading all aspects of validation (equipment, process, utilities, facilities, CSV) and support...
-
ASIC Design Verification Engineer
1 month ago
Saint Paul, United States ForwardEdge ASIC (a Lockheed Martin Company) Full time $150,000 - $200,000Job DescriptionJob DescriptionCompany Summary: Join our talented team at ForwardEdge ASIC, an industry leading ASIC design company. We are committed to pushing the boundaries of technology through cutting-edge ASIC designs that redefine industry standards. As an ASIC Design Verification Engineer, you will play a pivotal role in ensuring the robustness and...
-
Principal Engineer I
1 month ago
Saint Louis, United States SPECTRUM Full timeSpectrum's Product and Technology team creates, develops, and operates the nation's fastest mobile service, most reliable internet service, most viewed live TV app, and the most advanced WiFi, serving nearly 100 million users and 500 million devices. We are transforming the next era of connectivity and entertainment experiences. The diversity of experience...
-
Principal Mechanical Engineer
3 weeks ago
Saint Cloud, United States LCI-Lawinger Consulting Full timeJob DescriptionJob DescriptionOur Client is seeking a Principal Mechanical Engineer to lead projects. This is a direct hire role / hybrid. As a Principal Mechanical Engineer, you’ll lead a path of innovation, ingenuity, and technical excellence. Your key responsibilities will include:Overseeing all technical aspects of projects, collaborating with...
-
Research Scientist
21 hours ago
St Louis, Missouri, United States Washington University in St. Louis Full timeSchedule and Position SummaryThe Walsh lab is seeking a highly motivated scientist to contribute to our research on the ocular immune system. We employ a multidisciplinary approach, combining imaging, molecular, and flow-cytometry techniques to investigate the impact of the immune system on eye function in both health and disease.Job ResponsibilitiesConduct...
-
Clinical Research Coordinator
2 months ago
Saint Louis, United States St. Louis Heart and Vascular Full timeJob DescriptionJob DescriptionSUMMARY:Under general supervision, the primary function of the Clinical Research Coordinator is to coordinate the conduct of cardiovascular clinical research protocols in the in-hospital and clinic settings with an emphasis on the screening, enrollment, and monitoring of patient candidates/participants.ESSENTIAL FUNCTIONS (ROLES...
-
Imaging Systems Scientist
3 weeks ago
St Louis, Missouri, United States Peraton Full timeJob Title: Image Scientist at PeratonRole OverviewWe are seeking a driven IMAGE SCIENTIST to contribute to a variety of product assessments, algorithm quality studies, new product launches, and the formulation of equations to evaluate image quality in imaging technologies.The ideal candidate will possess hands-on experience and a comprehensive understanding...
-
Medical Laboratory Scientist
3 months ago
Saint Helena, United States Avera Sacred Heart Hospital Full timeJoin the team at Avera! Award Winning Health Care: Avera has been named among the nation’s 15 Top Health Systems, Forbes list of America’s Best-in-State Employers and Level 10 Most Wired Health Care Organization by CHIME. Culture: Be part of a multidisciplinary team built on teamwork, with compassion and the goal of Moving Health Forward for...
-
Lead Clinical Research Investigator
3 weeks ago
St Louis, Missouri, United States Denali Health Full timePosition Overview:Denali Health is in search of a skilled and knowledgeable Lead Clinical Research Investigator to spearhead and oversee clinical research initiatives within our organization. The Investigator will play a crucial role in ensuring the quality, safety, and efficacy of clinical trials by managing all facets of study design, implementation, and...
-
Lead Clinical Research Investigator
3 weeks ago
St Louis, Missouri, United States Denali Health Full timePosition Overview:Denali Health is in search of a skilled and knowledgeable Lead Clinical Research Investigator to spearhead and oversee clinical research initiatives within our organization. The Investigator will play a crucial role in maintaining the integrity, safety, and efficacy of clinical trials by managing all facets of study design, implementation,...
-
Medical Laboratory Scientist
2 months ago
Saint Helena, United States Avera Sacred Heart Hospital Full timeJoin the team at Avera! Award Winning Health Care: Avera has been named among the nation’s 15 Top Health Systems, Forbes list of America’s Best-in-State Employers and Level 10 Most Wired Health Care Organization by CHIME. Culture: Be part of a multidisciplinary team built on teamwork, with compassion and the goal of Moving...
-
Part Time Research Technician
3 days ago
Saint Louis, United States Beacon Hill Pharma Full timeJob DescriptionJob DescriptionThis position will be about 20 hours per week, supporting Rhizosphere Research scientists by assisting in the production of inoculum for arbuscular mycorrhizal fungal (AMF) research. This role is primarily laboratory-based. Prior experience isbeneficial, but training will be provided. Principal Responsibilities: • Adhere...
-
Research Scientist
7 days ago
Port Saint Lucie, Florida, United States Cleveland Clinic Full timePostdoctoral Fellow OpportunityWe are seeking a highly motivated and experienced Postdoctoral Fellow to join our team at the Cleveland Clinic. This training position will provide practical experience in a research setting, under the direct supervision of a Principal Investigator.Responsibilities:Design and execute independent research projects with the goal...
-
Medical Laboratory Scientist
2 months ago
Saint Helena, United States Avera Sacred Heart Hospital Full timeJoin the team at Avera! Award Winning Health Care: Avera has been named among the nation’s 15 Top Health Systems, Forbes list of America’s Best-in-State Employers and Level 10 Most Wired Health Care Organization by CHIME. Culture: Be part of a multidisciplinary team built on teamwork, with compassion and the goal of Moving Health Forward...
-
Medical Laboratory Scientist
2 weeks ago
Saint Helena, United States Avera Sacred Heart Hospital Full timeJoin the team at Avera! Award Winning Health Care: Avera has been named among the nation’s 15 Top Health Systems, Forbes list of America’s Best-in-State Employers and Level 10 Most Wired Health Care Organization by CHIME. Culture: Be part of a multidisciplinary team built on teamwork, with compassion and the goal of Moving Health Forward...
Sr Scientist/ Principal Investigator- Oligonucleotide Bioanalysis
3 months ago
Position Title
Senior Scientist/ Principal Investigator -Oligonucleotide Bioanalysis
We are inviting an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a collaborative culture and mutual respect. Our site is part of a 2400 person growing publicly traded international organization with over 15 sites. We recently made a $4.5MM investment in our site.
The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology, and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.
This position will be part of a newly created group at our site supporting groups at another site. In the beginning, there will be one person at the site. The goal is to grow the group and this would become a contributing leadership position of the newly formed group.
Objectives:
- Independently designs and implements novel Bio/-analytical methods to support research projects relating to the development of antisense or siRNA Oligonucleotide based therapeutics.
- Develop and implement innovative high-resolution mass spectrometry-bases metabolite profiling and identification assays.
- Act as an oligonucleotide bio/-analytical SME and work cross-functionally to build internal capabilities.
Position Requirements
Education and experience
- BS or equivalent degree in Chemistry, Biochemistry, or related field, and greater than 15 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or,
- MS in Chemistry, Biochemistry, or related field, and 7 to 10 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or,
- Ph.D. in Chemistry, Biochemistry, or related field and 3 to 5 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management
- 5-10 years specific experience with Oligonucleotides
Skills and abilities
- Proven track record of scientific contributions in the development of oligonucleotide analytical and bioanalytical methods to support oligonucleotide delivery platform development.
- Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/ in vivo pharmacology, ADME, PK/PD, translational research, and toxicology)
- Working knowledge and awareness of general laboratory procedures.
- Displays versatility and accuracy performing laboratory operations, some of which may be difficult and/or non-routine.
- Strong and effective manager and mentor of junior scientists
- Ability to use a computer to compile and maintain databases for records and inventory, utilizing the appropriate software.
- Ability to adhere to all safety regulations and procedures.
- In-depth knowledge and specific understanding of analytical testing needed in drug discovery as it relates to quantitating, characterizing, and further understanding the metabolic fate of ASO and siRNA-based therapeutics and conjugates thereof.
- Support LC-MS instruments operation, daily maintenance, and troubleshooting.
- An attitude for quality, an eye for detail, the ability to follow written instructions and work with a minimum of supervision.
Full and comprehensive benefits package including Medical/Dental/Vision insurance, 401k, bonus potential, and vacation.
This role is a full-time permanent position.
