Research Associate II

3 weeks ago

Cambridge MA United States Skills Alliance Full time

Our client is an amazing place - we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. Embedded within the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional scientists. Our mission is to translate the deep biological insights originating from the community into impactful drug discovery projects. We connect faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners to execute exciting drug discovery projects. We combine our expertise in drug discovery with the knowledge and unique capabilities of our client to address a wide range of disease areas including oncology, cardiovascular and metabolic diseases, psychiatric disorders, infectious disease, and rare diseases. Our goal is to embrace our client's culture of creativity and open sharing to de-risk therapeutic hypotheses, validate new targets, and advance new therapies that will improve human health. Our clients is committed to increasing the diversity across the institute. Candidates who have experience working with a diverse range of staff and who can contribute to the climate of belonging and inclusivity are encouraged to identify their skills in these areas when applying.

We are currently seeking a highly motivated and passionate research associate to support drug discovery projects. We will provide cutting-edge protein sciences and structural biology professional training to support the candidate in driving therapeutic discovery at the bench through the production, characterization and crystallization of therapeutic protein targets. The successful candidate will have a solid understanding of protein biochemistry and molecular biology. Experience in structural biology is advantageous.

CHARACTERISTIC DUTIES

Developing and executing strategies to clone and express recombinant proteins in a variety of cell culture systems

Purifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)

With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinement

Supporting the crystallographic pipeline through protein design, expression, purification, and biophysical characterization

Demonstrating the ability to interpret experimental outcomes and proposing follow-up studies

Documenting work, managing, analyzing and effectively presenting results to multi-disciplinary project teams

Working in partnership with team members and collaborators to best achieve results

QUALIFICATIONS

B.S. or M.S. in Molecular Biology, Biochemistry, Biophysics or a related life science field with 0-2 years research experience in an academic or industrial setting

Experience with molecular cloning and vector construction, bacterial expression, and protein purification through conventional and affinity-based chromatographic approaches is desired

Experience in the functional characterization of recombinant proteins and biophysical characterization of protein-protein and/or protein-small molecule interactions is desired

Knowledge in protein crystallography, cryo-EM, or NMR is advantageous

A proven record of successful communication and interaction with project team members, external customers or vendors is advantageous

The successful candidate will be a results-focused, team-oriented scientist able to excel in a fast-track environment across multiple projects. They must be accountable, self-motivated, detail-oriented and exhibit problem solving skills. In addition, the successful candidate will be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with team members.

WORKING CONDITIONS

Normal laboratory conditions

Normal office conditions

All employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

EEO is The Law - click here for more information

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

LI-POST

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

EEO is The Law - click here for more information

Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled

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