Senior Scientist, Downstream Process Development
2 days ago
Here at Kelonia Therapeutics, we aren’t just a preclinical company; we’re trailblazers in viral engineering, pushing the boundaries of in vivo lentiviral gene and cell therapy. We're not just a team; we're dreamers on a mission to bring the promise of cell and gene therapy to every patient in need.
At Kelonia, we've gathered a group of pioneers in cell and gene therapy to lead our journey, with extraordinary scientific founders at the helm, providing the cutting-edge technology that sets us apart. We're not just building a company; we're cultivating a culture—one that values both skill and care.
Are you ready to be a part of our remarkable journey? We're looking for someone exceptional to join our growing team as a Sr. Scientist, Downstream in the Process Development group. This isn't just a job; it's an opportunity to contribute to groundbreaking therapies, to be part of a company's inception, and to make a transformative impact on patients' lives. If you're passionate about scaling a company from the ground up, making a real difference, and shaping the inclusive culture we're proud of, this opportunity is tailor-made for you. Join us and be a driving force in achieving excellence in viral engineering.
What You'll Do:- Serve as the primary expert in the purification of sterile, injectable gene therapy materials, ensuring processes meet high standards of purity and quality.
- Manage external partners to effectively scale up bench-scale processes through pilot, engineering, and manufacturing stages, ensuring smooth transitions and successful outcomes.
- Evaluate and implement novel chromatography and filtration techniques to enhance product purity.
- Oversee and conduct experimental planning, execution, analytical testing, data analysis, and reporting, ensuring thorough and accurate results.
- Author and review technical documents, including study protocols, reports, and regulatory submissions.
- Work closely with Research, Upstream Process Development, Formulation Development, and Analytical groups to achieve top-tier product purity and potency.
- Mentor and provide technical guidance to junior scientists and team members.
- Occasional travel (up to 10%) may be required to support development efforts with external partners.
- Strong scientific expertise in Biochemical Engineering, Biochemistry, Chemical Engineering, or a related field.
- Substantial experience in developing purification processes for gene therapy or protein products, with proven success in scaling up processes for clinical manufacturing.
- Hands-on experience with AKTA systems and Unicorn automation.
- Proficient with various filtration strategies such as ATF, TFDF, TFF, NFF, and related control systems/skids.
- Demonstrated ability to work effectively within cross-functional teams, manage multiple priorities, and meet deadlines.
- Adaptable and resourceful problem solver with a proactive, “get-it-done” attitude.
- Excellent written and verbal communication skills, with strong attention to detail and strong organizational capabilities.
- Familiarity with bioanalytical techniques (flow cytometry, ELISA, qPCR) is a plus.
- Management, leadership, or mentorship experience is preferred but not required.
Our goal at Kelonia is to promote a healthy work/life balance and we hope the benefits we provide are a direct reflection of that goal. We offer a hybrid workplace that provides employees with flexibility to work in the office or remotely dependent on job responsibilities. We also offer a team-focused environment with a top-notch benefits package (health, dental, flexible PTO, and commuter) to match. Kelonia fosters a collaborative and inclusive workplace that allows you to become a part of a small team that places equal value on talent development and meeting company goals.
Kelonia Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Kelonia does not accept unsolicited resumes from any source other than directly from candidates.
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