Current jobs related to Scientist I/II, LNP - Boston - CRISPR Therapeutics

  • Senior Scientist 1

    1 month ago

    Boston, United States Amplitude Therapeutics Full time

    Company summary:Amplitude Therapeutics is a seed-staged biotechnology company focusing on developing the next generation of RNAs to fully unlock the therapeutic potential of RNA biology. We are founded by leaders in the RNA and non-viral therapy fields and backed by premier Biotech VCs.Position summary:Amplitude Therapeutics is seeking a highly motivated...

  • Scientist I/II, Analytical Development

    3 weeks ago

    boston, United States PepGen Full time

    Scientist I/II, Analytical Development The Scientist, Analytical Development will be a key member of the Analytical Development group at PepGen. The successful candidate will have great opportunities to use state-of art instruments for studying various potential drug candidates to ultimately create transformational therapies for patients with neuromuscular...

  • Scientist I/II, Analytical Development

    3 weeks ago

    boston, United States PepGen Full time

    Scientist I/II, Analytical Development The Scientist, Analytical Development will be a key member of the Analytical Development group at PepGen. The successful candidate will have great opportunities to use state-of art instruments for studying various potential drug candidates to ultimately create transformational therapies for patients with neuromuscular...

  • Scientist I/II, Analytical Development

    4 months ago

    Boston, United States PepGen Full time

    Scientist I/II, Analytical Development The Scientist, Analytical Development will be a key member of the Analytical Development group at PepGen. The successful candidate will have great opportunities to use state-of art instruments for studying various potential drug candidates to ultimately create transformational therapies for patients with neuromuscular...

  • Scientist I/II, Analytical Development

    4 months ago

    Boston, United States PepGen Full time

    Job DescriptionJob DescriptionScientist I/II, Analytical DevelopmentPosition Summary The Scientist, Analytical Development/CMC will be a key member of the Analytical Development group at PepGen. The successful candidate will have great opportunities to use state-of art instruments for studying various potential drug candidates to ultimately create...

  • Research Scientist II

    10 hours ago

    Boston, Massachusetts, United States Mass General Brigham Full time

    Job Title: Research Lab Tech IIJob Summary:The Research Lab Tech II position involves conducting research and administrative tasks in a laboratory setting. Under the supervision of the Principal Investigator, the Research Lab Tech II will conduct independent and collaborative research involving molecular biology and microbiology techniques.Key...

  • Associate Scientist

    4 hours ago

    Boston, United States Integrated Resources, Inc Full time

    Job DescriptionJob DescriptionJob Title: Associate Scientist - IIJob Location: Boston, MAJob Duration: 23 Months+Roles & Responsibilities:Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to develop therapeutics that are effective aProductst intended...

  • Scientist II, Assay Development and Screening Specialist

    17 hours ago

    Boston, Massachusetts, United States 1910genetics Full time

    Join Our Team as a Scientist II, Assay Development and ScreeningWe are seeking a highly skilled Scientist II, Assay Development and Screening to join our Biology Department at 1910 Genetics. As a key member of our team, you will be responsible for implementing and executing in vitro assay development and screening strategies, assisting in lab automation,...

  • Lead Scientist, Advanced Analytical Techniques

    3 weeks ago

    Boston, Massachusetts, United States Verve Therapeutics, Inc. Full time

    Job OverviewCompany OverviewVerve Therapeutics, Inc. is a pioneering clinical-stage company focused on genetic medicine aimed at addressing the global health crisis of cardiovascular disease. Established by leading experts in cardiovascular health, human genetics, and gene-editing, Verve is at the forefront of transforming the treatment landscape from...

  • Food Scientist II

    3 weeks ago

    Boston, United States Chew CPG Inc Full time

    Job DescriptionJob DescriptionChew is a mission-driven food and beverage innovation company founded on the notion that consumers shouldn't have to choose between what tastes great and what’s good for you.DELICIOUS. NUTRITIOUS. SUSTAINABLE. PROFITABLE. SCALABLE.We are looking for a balance between creative and pragmatic - someone self-motivated and...

  • Food Scientist II

    2 weeks ago

    Boston, United States Chew CPG Inc Full time

    Job DescriptionJob DescriptionChew is a mission-driven food and beverage innovation company founded on the notion that consumers shouldn't have to choose between what tastes great and what’s good for you.DELICIOUS. NUTRITIOUS. SUSTAINABLE. PROFITABLE. SCALABLE.We are looking for a balance between creative and pragmatic - someone self-motivated and...

  • Sr. Director

    1 month ago

    Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...

  • Sr. Director

    4 weeks ago

    Boston, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...

  • Medical Lab Scientist II, Hematology

    4 weeks ago

    Boston, United States Brigham and Womens Hospital Full time

    Job Description – Medical Lab Scientist II, Hematology ()Medical Lab Scientist II, Hematology – ()Role & ResponsibilitiesPerforms blood, urine and body fluid tests on humans with speed, method, precision and understanding of theory behind tests; studies morphology of constituents of blood to obtain data for use in diagnoses and treatment of disease.Gains...

  • Computational Research Scientist I, Neurosurgery

    3 weeks ago

    Boston, Massachusetts, United States Brigham and Women's Hospital Full time

    Job Title: Computational Research Scientist I, NeurosurgeryCompany: Brigham and Women's HospitalRequirements:• Bachelor's Degree in Computer Science, Engineering, Physics, or related field.• Prior experience in computational biology, statistics, deep learning algorithms, or genetics is highly valued.• We seek a candidate with strong attention to...

  • Scientist I

    4 weeks ago

    Boston, United States eTeam Full time

    Title: Scientist - I (Assistant) - MA OnlyLocation : Boston, MADuration: 12 months’Pay rate: $27 hr.Responsibilities:The responsibilities of the candidate include but are not limited to:• Assist in developing, executing, and troubleshooting new cell-based assays, protocols, and analysis methods.• Design and execute experiments, interpret data, and...

  • Scientist I

    3 weeks ago

    boston, United States eTeam Full time

    Title: Scientist - I (Assistant) - MA OnlyLocation : Boston, MADuration: 12 months’Pay rate: $27 hr.Responsibilities:The responsibilities of the candidate include but are not limited to:• Assist in developing, executing, and troubleshooting new cell-based assays, protocols, and analysis methods.• Design and execute experiments, interpret data, and...

  • Scientist I

    1 month ago

    Boston, United States eTeam Full time

    Title: Scientist - I (Assistant) - MA OnlyLocation : Boston, MADuration: 12 months’Pay rate: $27 hr.Responsibilities:The responsibilities of the candidate include but are not limited to:• Assist in developing, executing, and troubleshooting new cell-based assays, protocols, and analysis methods.• Design and execute experiments, interpret data, and...

  • Scientist I

    3 weeks ago

    boston, United States eTeam Full time

    Title: Scientist - I (Assistant) - MA OnlyLocation : Boston, MADuration: 12 months’Pay rate: $27 hr.Responsibilities:The responsibilities of the candidate include but are not limited to:• Assist in developing, executing, and troubleshooting new cell-based assays, protocols, and analysis methods.• Design and execute experiments, interpret data, and...

  • Biochemistry Scientist II/Senior Researcher

    3 weeks ago

    Boston, Massachusetts, United States NextRNA Therapeutics Full time

    As a Biochemistry Scientist II / Senior Researcher at NextRNA Therapeutics, you will be part of a dynamic and innovative team dedicated to enhancing patient outcomes through advanced RNA-targeted therapies. Your role will be pivotal in merging biochemical methodologies with our drug development initiatives. About You:You possess a wealth of experience in...

Scientist I/II, LNP

4 months ago

Boston, United States CRISPR Therapeutics Full time

Company Overview

Since its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United Kingdom

Position Summary
The candidate will be leading our efforts in the design and execution of novel and existing lipid nanoparticle (LNP) formulations to help advance our non-viral delivery platform and take next-gen editing modalities for bespoke indications from concept to clinical application. We are searching for a driven, enthusiastic, and self-motivated individual who is comfortable multitasking and working independently as well as part of a larger team on various aspects of in-vivo delivery. This individual will join the dynamic, rapidly growing, and highly collaborative CRISPR-X division.

Responsibilities
  • Design, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervision
  • Determine key formulation parameters to provide reproducible and effective LNPs.
  • Lead the production and characterization of LNPs for various studies enabling a clinical applications.
  • Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.
  • Be highly organized and meticulous in documenting results in electronic lab notebooks, and present findings to the broader team.
  • Effectively multitask and manage multiple projects simultaneously.
  • Stay up to date on in-vivo delivery literature and industrial practice.
Minimum Qualifications
  • Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or related field and
    • Scientist I: 0-2 years of relevant experience
    • Scientist II: 2-5+ years of relevant experience
  • Extensive hands-on experience and deep expertise in formulating LNPs for gene editing applications in human health.
  • Hands on experience with HPLC, DLS, Ribogreen, TEM and other analytical methods.
  • Pays great attention to details in the quality and reproducibility of the LNPs
  • Strong communication and troubleshooting skills.
  • A team player with strong interpersonal skills, and ability to collaborate effectively with others.
Preferred Qualifications
  • Prior experience in LNP conjugation chemistries for drug delivery
  • Prior experience in using LNPs in mammalian cell culture and animal models.
Competencies
  • Collaborative – Openness, One Team
  • Undaunted – Fearless, Can-do attitude
  • Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
  • Entrepreneurial Spirit – Proactive. Ownership mindset.