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Principal Scientist
4 months ago
HOW MIGHT YOU DEFY IMAGINATION?
If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever–better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.Principal Scientist – Clinical Pharmacology, Modeling and SimulationLive
What you will do
Lets do this. Lets change the world. Amgen Clinical Pharmacology Modeling and Simulation (CPMS) is seeking a Principal Scientist in our Thousand Oaks, CA location. As part of the Clinical Pharmacology, Modeling and Simulation department, the Modeling and Simulation. The Principal Scientist will support Amgen clinical development and translational sciences programs across multiple therapeutic areas with emphasis on oncology.Key responsibilities include:Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure–response analyses using relevant state of the art modeling and simulation techniques.Training in binary and categorical and binary data analyses, time–to–event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure–response analyses and Population PK and PKPD analysis.Perform meta–analysis using proprietary and/or literature data.Participate in cross–functional project teams and provide scientific input for dose selection, early and late phase study designs using modeling and simulation inputs.Contribute to clinical pharmacology strategy for the program(s) and implement project plans.Generate modeling reports and contribute to the summary documents for regulatory submissions.WinWhat we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications. Basic Qualifications: Doctorate degree PhD OR PharmD OR MD and relevant post–doc where applicable and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experienceOr Master s degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experienceOr Bachelor s degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience Preferred Qualifications:PhD in Pharmacometrics, Pharmaceutical sciences, Applied Statistics/Mathematics, Biostatistics, and/or Engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3+ years of PK/PD or statistical modeling experience.3+ years industry or relevant academic experience in pharmacometric analyses, data science, and/or applied biostatistics of small molecules and/or biologics.Proficiency in modeling software (e. g. NONMEM, R/S–Plus, STAN, Python, SAS, MATLAB)ThriveWhat you can expect of us As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well–being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.A discretionary annual bonus program, or for field sales representatives, a sales–based incentive planStock–based long–term incentivesAward–winning time–off plans and bi–annual company–wide shutdownsFlexible work models, including remote work arrangements, where possibleApply nowfor a career that defies imagination Objects in your future are closer than they appear. Join us. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
