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Post

4 months ago

Pittsburgh, Pennsylvania, United States University of Pittsburgh Full time

Post Doctoral.Post Doctoral.Associate
Med-Medicine - Pennsylvania-Pittsburgh

The Department of Medicine, Division of Cardiology and Vascular Medicine Institute is seeking two Postdoctoral Associates. The interest of this academic laboratory and newly formed Center for Immunometabolism (PI and Director: Babak Razani, ) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages and immunometabolic processes. We and others have shown that perturbations in cellular processes involving mTOR and nutrient sensing, autophagy and lysosomes, and inflammatory signaling including inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease. Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017; Evans, et al Science Signaling 2019; Zhang, et al Nature Metabolism 2020; Jeong, et al Autophagy 2021; Zhang, et al Circulation Research The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance.

These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell lines, mouse models, human monocytes/monocyte-derived macrophages, induced pluripotent stem cell (iPSC)-derived macrophages, and circulating monocytes and tissue macrophages from humans enrolled in clinical studies. Additionally, there is a recent focus for the lab on "omics" approaches to macrophage phenotyping and using CRISPR/Cas9 techniques to target newly identified genes for subsequent cellular and organismal phenotyping.

Primary Duties & Responsibilities:

1. Collaborates with the PI on the design, conduct, and reporting of research projects.

2. Assists with grant preparation and reporting. May submit grant proposals with the approval of the PI, Department Head, and Dean.

3. Prepares and submits papers on research.

4. Develop hypotheses to be tested and ways of testing them.

5. Complies with established safety procedures and maintains required documentation on laboratory and specimen conditions.

6. Manages research projects with other institutions and investigators.

Qualifications:

Candidates with prior experience in a cell, molecular biology, immunology, metabolism, or related fields with a Ph.D. degree in Molecular and Cellular Biology, Life

Science or related field.

Salary will follow NIH guidelines and will be adjusted by achievement.

Interested applicants should apply via Requisition #

The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.


Assignment Category: Full-time regular
Campus: Pittsburgh
Required Attachments: Curriculum Vitae
Optional Attachments: Cover Letter, Letters of Recommendation

Assignment Category Full-time regular

PI