Associate Scientist

3 weeks ago


New Haven, United States Meet Full time

Position Summary: The Neuroscience group is seeking a highly motivated Associate Scientist with an interest in central nervous system (CNS) diseases. This laboratory-based position offers an exciting opportunity to contribute to a dynamic and fast-paced team focused on the discovery and development of PROTACs (Proteolysis Targeting Chimeras). The ideal candidate will possess proficiency in basic biochemistry skills and cell culture, with a proven ability to deliver quality data in a timely manner while collaborating effectively with team members to support small molecule drug discovery efforts.


Principal Responsibilities:

  • Design and execute experiments and perform thorough data analysis.
  • Culture adherent and suspension mammalian cells; isolate and propagate clonal cell populations.
  • Evaluate target protein degradation utilizing techniques such as Western blotting, ELISA, or other related methods.
  • Document, compile, and interpret experimental data; maintain laboratory notebooks, databases, and spreadsheets to present data effectively.
  • Interact and collaborate with both biology and chemistry team members to advance drug discovery and development programs; present data at regular team meetings.


Qualifications:

  • B.S. or M.S. degree in Biology, Neuroscience, or a related field, with a minimum of 2 years of relevant laboratory experience demonstrating mastery of the techniques outlined above.
  • Demonstrated experience in methods for assessing protein levels in various bioassays (e.g., Western blots, ELISA, In Cell Western, or similar techniques).
  • Proficient in aseptic mammalian cell culture, including media preparation, cryopreservation, and clonal isolation and propagation.

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