Scientist

6 days ago

Worcester, United States Randstad Life Sciences US Full time

Title: Scientist

Location: Worcester, MA

Pay: $40-48/hr

Contract: 12+ months


Summary

  • The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivated research scientist to join in the newly formed Genetic Medicine (GM) group at Company Bioresearch Center (ABC). The ABC site, based in Worcester, MA, offers a unique setting where GM, Biologics drug discovery, development and manufacturing coexist in one location. Our team interacts with multidisciplinary groups across Company focused on developing therapies for Virology, Immunology, Neurology, Ophthalmology and Oncology diseases.
  • As an integral member of the GM team this individual will be critical in activities related to mRNA-LNP development, optimization, characterization, including LNP formulation (NanoAssemblr or Jet mixer), size, and surface potential measurement. The successful candidate is expected to have hands-on experience with tangential flow filtration (TFF) and sterile filtration. As one of the key team members this individual will work with the manager and scientists across different functional groups to discover and develop next generation non-viral genetic medicine. You will be relied on as a technical contributor to assess the assigned tasks that involve direct application of your knowledge. The candidate will need to have excellent verbal and written skills and the ability to clearly present scientific concepts and results.


Key Responsibilities:

  • Help in developing, producing, and characterizing lipid based nucleic acid formulations with targeting moieties for innovative drug products to support multiple internal programs.
  • The incumbent should be familiar with analytical techniques including but not limited to DLS, zeta potential, SDS-PAGE, ELISA, SEC and RiboGreen assay.
  • Work closely with manager and cross-functional team members on multiple projects simultaneously to collect and analyze data on project basis.
  • Under manager’s supervision interpret and summarize experimental data. Present experimental results at meetings as needed.
  • Assist in ordering supplies from internal inventory and prepare reagents & other supplies necessary for formulation work.
  • Maintain laboratory electronic notebooks (ELN) in compliance with the Company Laboratory Notebook Policy.
  • Stay updated and in compliance on all departmental and corporate training.


Key Qualifications:

  • BS in Chemistry, Chemical Engineering, Biological Engineering, or a related field with a minimum of 3-5 years of relevant industry experience. MS in biology, chemistry, biomedical engineering, or related field with 0-2 years of nanoparticle design and characterization experience.
  • Experience with tangential flow filtration (TFF) and sterile filtration.
  • Working knowledge of related tools/software (Prism, FlowJo, FACSDiva etc.).
  • Laboratory hands-on experience with nanoparticle formulation and characterization and stability studies.
  • Self-motivated, hard-working, detail-oriented, resourceful, and able to work in a fast-paced team environment with demonstrated problem solving and perseverance skills.
  • Good Computer skills including word processing, Excel, PowerPoint and relevant scientific software.


Key Competencies:

  • Builds strong relationships with peers and cross functionally with partners to enable higher performance.
  • Learns fast, grasps the "essence “and can change course quickly where indicated.
  • Open to suggestions and experimentation for improvement.
  • Strong interpersonal and communication skills with proven ability to work within a team environment.

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