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Scientist
4 months ago
Job Title: Oligonucleotide Scientist-2
Location: South San Francisco, CA
Duration:1 year
The Position
- We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Department of Protein Chemistry (PC) – ProteinSciences (PS).
- We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group.
- Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred.
- The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
Key Responsibilities
- The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
- Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
- Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
- Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
- Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
- Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
Requirements
- The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
- The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
- The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
- A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred.
- Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
- Good communication and interpersonal skills are essential and will be evaluated during the interview process.
- The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
