Senior Scientist – Stem Cell Biology

5 days ago

Cambridge, United States Eterna Therapeutics Full time

Senior Scientist – Stem Cell Biology (Contract – 6 months)

Qualifications

  • Ph.D. in Biology or related field and 1-3 years of experience
  • MS in Biology or related field and 5-6 years of experience
  • Experience in stem cell biology, immunology, cell therapy
  • Experience in iPSC is a plus
  • Experience in process development is a plus
  • Self-starter, detail oriented, multi-tasking with effective time management


Responsibilities

  • Design plan and execute a variety of cell-based assays to characterize the lead product
  • Execution of specialized cytotoxicity assay, cytokine profiling and immune-activation assays
  • Improve on the existing process development methodologies to streamline drug product manufacturing
  • Manage external efforts at CDMOs with collaborating partners, ensuring rigorous scientific standards are upheld.
  • Effectively communicate experimental methods and findings in both oral and written formats


This is a 6-month contract position with the possibility of extension


About Eterna Therapeutics

Eterna Therapeutics, a publicly traded, preclinical-stage cell therapy company. Company’s vision

is to improve the lives of patients with difficult-to-treat diseases through innovative, effective,

and safe, but accessible cellular therapies and mission is to develop allogenic off-the-shelf

cellular therapies, leveraging induced pluripotent stem cell (iPSC)-derived mesenchymal stem

cells (iMSCs) to target solid tumors. Eterna’s lead product ERNA-101 is allogenic IL-7 and IL-

15-secreting iMSC. ERNA-101 capitalizes on the intrinsic tumor-homing ability of MSCs to slip

through the tumor’s defenses and to deliver potent pro-inflammatory factors directly to the tumor

microenvironment (TME), limiting systemic exposure and potential toxicity while unleashing

potent anti-cancer immune responses including enhancement of T-cell anti-tumor activity. The

company’s initial focus is to develop ERNA-101 in platinum-resistant, tp53-mutant ovarian

cancer (PROC) and triple negative breast cancer (TNBC). Eterna is expecting to complete the

Investigational New Drug (IND) enabling studies and IND submission by 2026. The company is

also planning to investigate anti-inflammatory cytokine (e.g. IL-10)-secreting iMSCs in

inflammatory/auto-immune disorders like Rheumatoid arthritis. The company is actively seeking

strategic partnerships to co-develop or out-license therapeutic assets and engage with potential

collaborators to expand developmental opportunities.

We are a small, nimble company with a passion for scientific excellence, a keen sense of

urgency, laser focus and significant growth potential.

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