Process Development Scientist

3 weeks ago


Pennington, United States EPM Scientific Full time

We are currently working with a Gene Therapy company that are looking for a Scientist/Engineer to join their process development downstream team.


The successful applicant will have experience in laboratory research, and a desire to continue in a laboratory-focused role. This position will join a team of scientists/engineers focused on developing and optimizing AAV (Adeno-Associated Virus) manufacturing processes for gene therapy products for early- and late-phase clinical trials.


Responsibilities:

  • Execute lab experiments to support the development of efficient, robust, scalable and cost-effective AAV downstream manufacturing process.
  • Participate in the experimental design planning and execution of viral vector purification experiments to increase product yield and process understanding.
  • Support the downstream development of AAV manufacturing process to optimize the viral vector purification steps (chromatography, filtration, tangential flow filtration (TFF/UFDF)).
  • Optimize purification process conditions and buffer screening using DOE and JMP; Perform troubleshooting experiments, and communicate findings with appropriate working groups.
  • Document experiments, analyze and interpret process and analytical data, and summarize findings in lab notebook entries and reports.
  • Contribute to technical reports, data summaries, tech transfer reports. Present results in internal meetings.
  • Interact with internal and external partners. Support downstream process tech transfer, scale-up, clinical and commercial manufacturing as needed.


Requirements:

  • BS or MS degree in Biochemistry, Biological Engineering, Chemical Engineering, or related discipline.
  • More than 3 years of hands-on laboratory experience.
  • In depth understanding, and hands on experience in AAV or relevant biologics downstream purification including harvest, depth filtration, TFF/UFDF, preparative chromatography, and membrane chromatography.


Contract:

  • 40 hours per week
  • Start date: Early December
  • Contract length: 6 months
  • Pennington, NJ
  • W2 only

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