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Scientist, in vivo mRNA

4 months ago

Boston, United States CRISPR Therapeutics Full time

Company Overview

Since its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United Kingdom.

Position Summary

CRISPR Therapeutics is seeking a highly passionate, creative, and motivated mRNA scientist to join our In Vivo Technical Operations department in Boston, Massachusetts. The incumbent will be responsible for the mRNA synthesis, purification, formulation, and analysis to support the process development of mRNA production in various scales. This candidate will work cross-functionally with R&D program teams in the early-stage development and provide strategic and technical support as the programs advance into manufacturing stage.

Responsibilities

  • Implement and optimize the process for mRNA synthesis, purification, and purification.
  • Characterize mRNA for purity determination and impurity profiling.
  • Manage lab instruments and reagent inventory
  • Maintenance of an accurate and up-to-date record of experiments and results in the form of ELN entries and written reports
  • Communication of key findings in group and cross-functional team meetings
  • Contribution to regulatory and IP filings
  • Performance of laboratory work in safe, efficient manner that ensures a safe working environment for all colleagues

Minimum Qualifications

  • PhD degree in Bioengineering, Molecular Biology, Biochemistry, Pharmaceutical Sciences, or related field
  • At least 2 years of experience working in an industry lab with a proven record of developing and executing novel mRNA upstream and downstream process.
  • Strong hands-on skills, organizational skills, and attention to details in laboratory benchwork
  • Fundamental knowledge in RNA chemistry, gene editing and non-viral delivery system.
  • A learner’s mindset with a commitment to personal growth and a drive to broaden technical skills and scientific knowledge.
  • Willingness to invest in communications and scientific engagements with colleagues
  • Ability to think strategically, efficiently manage time and workflows, and work both independently and collaboratively in a cross-functional team environment.

Preferred Qualifications

  • Prior experience with mRNA upstream and downstream process development
  • Prior experience with immortalized or primary cell culture handling and transfection.
  • Working experience with analytical techniques (such as Bioanalyzer, UPLC) and data interpretation
  • Working experience with python language is desired.

Competencies

  • Collaborative – Openness, One Team
  • Undaunted – Fearless, Can-do attitude
  • Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
  • Entrepreneurial Spirit – Proactive. Ownership mindset.