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Principal Scientist

3 months ago

Bothell, Washington, United States Pfizer, S.A. de C.V Full time
Pfizers purpose is to deliver breakthroughs that change patients lives.

Research and Development is at the heart of fulfilling Pfizers purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most.

Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

You will participate in pre-clinical oncology drug discovery and development projects, with a focus on ADC Discovery.

You will apply analytical chemistry principals, biological techniques, and biochemical understanding to deepen our knowledge of how payloads are released from ADCs, as well as how unconjugated payloads behave in biological systems and matrices.

You will be responsible for working with project teams to design, plan and execute an analytical and chemical biology strategy, commensurate with each projects stage, to provide data and interpretations that enable efficient and effective decision-making regarding linker payload characteristics.

You will provide technical and scientific expertise to continue to grow our small molecule mass spectrometry capabilities and lead the development of new and improved techniques for their characterization, with efficiency and speed.

You will also participate in collaborative, cross-functional teams to enable cancer therapeutic development and aid in exploring scientific questions surrounding the role of the payload in antibody-based therapeutic activity and behavior.

How You Will Achieve It

Develop novel LC and MS methods for quantitative and qualitative analysis of small molecules of different therapeutic classes.

Design, optimize, execute, troubleshoot, and interpret experiments to analyze and quantify small molecules released from ADCs in fit-for-purpose biological matrices and systems.

Serve as a subject matter expert in bioanalytical quantitative LC-MS/MS to advise and guide individuals and cross-functional teams requiring quantitative small molecule analysis.

Maintain detailed and accurate laboratory records to create and organize technical information to deliver effective summaries and presentations.
Prioritize and execute tasks in a fast-paced work environment.
Cultivate innovation by evaluating and implementing new technologies and optimizing processes.
Build and continuously optimize workflows and database infrastructure for request intake, data management, and data democratization.
Assist junior associates or mentoring junior colleagues on LC-MS instrumentation experiments.
Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research.
Qualifications

Must-Have

Ph.
D. degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 4 + years related analytical chemistry experience in the biopharmaceutical industry OR
M.S. degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 9+ years related analytical chemistry experience in the biopharmaceutical industry OR
B.S.

degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 12+ years related analytical chemistry experience in the biopharmaceutical industry.

Contemporary knowledge of the key Analytical Chemistry, Biochemistry, and/or Chemical Biology concepts required for pharmaceutical drug discovery.
Established expertise in liquid chromatography and spectroscopy techniques, with examples of high impact scientific work in the biopharmaceutical industry.
Hands on experience working with, and troubleshooting, SCIEX, Thermo Scientific, and Waters LC-MS instrumentation and their software packages.
Nice-to-Have

Hands on experience working with high resolution mass spectrometry instrumentation and data analysis.
Familiarity with various extraction techniques of peptides, metabolites, and small molecules from biological matrices.
Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth.
Experience or familiarity with automation of processes involved in sample preparation and performance of mass spectrometry methods.
Established safe laboratory skills and accurate record keeping.
Ability to work independently on routine experiments.
Ability to collaborate across teams and a variety of disciplines.
Strong communication skills, both verbal and written.
Prior people management experience overseeing small groups and leading projects.
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
Why Patients Need You

Pfizers purpose is to deliver breakthroughs that change patients lives.

Research and Development is at the heart of fulfilling Pfizers purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most.

Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

You will participate in pre-clinical oncology drug discovery and development projects, with a focus on ADC Discovery.

You will apply analytical chemistry principals, biological techniques, and biochemical understanding to deepen our knowledge of how payloads are released from ADCs, as well as how unconjugated payloads behave in biological systems and matrices.

You will be responsible for working with project teams to design, plan and execute an analytical and chemical biology strategy, commensurate with each projects stage, to provide data and interpretations that enable efficient and effective decision-making regarding linker payload characteristics.

You will provide technical and scientific expertise to continue to grow our small molecule mass spectrometry capabilities and lead the development of new and improved techniques for their characterization, with efficiency and speed.

You will also participate in collaborative, cross-functional teams to enable cancer therapeutic development and aid in exploring scientific questions surrounding the role of the payload in antibody-based therapeutic activity and behavior.

How You Will Achieve It

Develop novel LC and MS methods for quantitative and qualitative analysis of small molecules of different therapeutic classes.

Design, optimize, execute, troubleshoot, and interpret experiments to analyze and quantify small molecules released from ADCs in fit-for-purpose biological matrices and systems.

Serve as a subject matter expert in bioanalytical quantitative LC-MS/MS to advise and guide individuals and cross-functional teams requiring quantitative small molecule analysis.

Maintain detailed and accurate laboratory records to create and organize technical information to deliver effective summaries and presentations.
Prioritize and execute tasks in a fast-paced work environment.
Cultivate innovation by evaluating and implementing new technologies and optimizing processes.
Build and continuously optimize workflows and database infrastructure for request intake, data management, and data democratization.
Assist junior associates or mentoring junior colleagues on LC-MS instrumentation experiments.
Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research.
Qualifications

Must-Have

Ph.
D. degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 4 + years related analytical chemistry experience in the biopharmaceutical industry OR
M.S. degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 9+ years related analytical chemistry experience in the biopharmaceutical industry OR
B.S.

degree in Analytical Chemistry, Biochemistry, Chemical Biology, or related area of science with minimum 12+ years related analytical chemistry experience in the biopharmaceutical industry.

Contemporary knowledge of the key Analytical Chemistry, Biochemistry, and/or Chemical Biology concepts required for pharmaceutical drug discovery.
Established expertise in liquid chromatography and spectroscopy techniques, with examples of high impact scientific work in the biopharmaceutical industry.
Hands on experience working with, and troubleshooting, SCIEX, Thermo Scientific, and Waters LC-MS instrumentation and their software packages.
Nice-to-Have

Hands on experience working with high resolution mass spectrometry instrumentation and data analysis.
Familiarity with various extraction techniques of peptides, metabolites, and small molecules from biological matrices.
Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth.
Experience or familiarity with automation of processes involved in sample preparation and performance of mass spectrometry methods.
Established safe laboratory skills and accurate record keeping.
Ability to work independently on routine experiments.
Ability to collaborate across teams and a variety of disciplines.
Strong communication skills, both verbal and written.
Prior people management experience overseeing small groups and leading projects.
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

Relocation support available

Work Location Assignment:
On Premise


The annual base salary for this position ranges from $99,900.00 to $166, In addition, this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments.

Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Learn more at Pfizer Candidate Site U.S. Benefits | ). Pfizer compensation structures and benefit packages are aligned based on the location of hire.

The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.

These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure.

Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.

Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.

If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.

Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development

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