Director of Antibody Therapeutics

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Job Title:Director of Antibody Therapeutics (Professor)Department:Medicine | School Biomedical Sciences Molecular Medicine and Therapeutics

Tenure faculty (regardless of rank) - persons with the titles of professor, associate professor, assistant professor and instructor who serve on appointments totaling 50% or more service to the university and who are eligible for tenure or who have obtained tenure. Duties and responsibilities are assigned in accordance with the workload guidelines laid out in the pattern of administration of each faculty member’s tenure initiation unit (TIU) and, as appropriate, regional campus; obligations will include research, service and/or teaching or clinical practice. These faculty will have earned doctorate or other terminal degree in the relevant field of study or possession of equivalent experience.

Additional Information:

Position Overview

The Department of Molecular Medicine and Therapeutics (MMT) and the Pelotonia Institute for Immuno-Oncology (PIIO) at The Ohio State University (OSU) College of Medicine, OSU Wexner Medical Center and OSU Comprehensive Cancer Center and James Cancer Hospital (OSUCCC-James) invite applications for a senior-level, tenured full professor position to lead a new Antibody Therapeutics Program. We seek an outstanding scientist with a distinguished track record of research in antibody discovery (using single cell cloning, structural biology-based design, functional screening, artificial intelligence etc), engineering including humanization, Fc optimization, bispecific or multi-specific targeting, antibody-drug conjugates, chimeric antigen receptors development, etc., with a focus on cancer immunotherapy. Well qualified faculty will be offered a competitive salary and generous start-up funding.

Performance Objectives

The objective of this role is to lead a program in MMT and PIIO to lead an innovative and integrated antibody therapeutics program to extend outstanding work ongoing at OSU with the objective to create an internationally leading program in novel antibody-directed therapeutics. This individual will be a leader both in MMT and in PIIO fostering collaborations across OSU.

Education and Experience Requirements

Required: Applicants must hold advanced degrees such as a PhD, DVM, PharmD, MD, or MD/PhD. Applicants must have a national and international reputation in antibody discovery and engineering, and significant independent research experience with both historical and current federal funding of research projects as a Principal Investigator. MMT is a basic science department. For candidates who require a clinical appointment, a co-appointment with a clinical Department is required and will be considered provided they are board-certified and meet medical licensure requirements in the State of Ohio.

Desired: Current or historical experience leading multi-component grants (e.g., P01, SPORE, U awards) desired. Applicants should have an accomplished history of mentorship and deep experience with team science.

How to Apply

To be considered, please submit your application electronically via Workday. Application materials must include the following items and only complete applications will be considered.

Required:

• Curriculum Vita (CV)
• Statement of Research
• Statement of Teaching and Mentoring

Department of Molecular Medicine and Therapeutics (MMT)

MMT, led by Matthew D. Ringel, MD, is a new basic science department in the College of Medicine. The vision of the department is to link fundamental science to translational research through collaboration and synergies within the OSU environment, accelerating translation of fundamental science to improve health.

The department emphasizes three thematic scientific areas: 1) Foundational therapeutics from drug design through development and validation; 2) tissue engineering and stem cell biology; and 3) molecular medicine and systems biology. The department draws on interdepartmental and college collaborations, partnering closely with the OSU College of Medicine, OSU Comprehensive Cancer Center and the James Cancer Hospital (OSUCCC-James) and the Dorothy M. Davis Heart and Lung Research Institute (DHLRI) to emphasize research in translational science.

Current MMT faculty have partnerships with both the OSUCCC-James and DHLRI, mechanisms of cancer progression and predisposition, cancer metabolism and immunotherapy, cardiac and basic fribroblast biology, calcium signaling, and systems biology. Faculty are funded by National Institutes of Health, Department of Defense, and the American Heart Association, highlighting the diverse, yet impactful nature of MMT research. MMT faculty also participate and are members in the Biomedical Sciences Graduate Program (BSGP), the Ohio State Biochemistry Program (OSBP), and others enabling teaching opportunities in courses and in the laboratory.

Pelotonia Institute for Immuno-Oncology

The PIIO is a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels. Established by a pledge of more than $100 million from Pelotonia, the PIIO represents Ohio State's commitment to grow the exciting area of immuno-oncology. Led by founding director Zihai Li, MD, PhD, the PIIO builds upon a rich portfolio of active investigator-initiated IO clinical trials being conducted at the OSUCCC-James. Its external advisory board is comprised of multiple world leaders in the field of IO including Drs. Lieping Chen, Carl June, Sue Kaech, Miriam Merad, Drew Pardoll, and Jennifer Wargo.

Research in the PIIO includes innate immunity (dendritic cells, macrophages, NK cells, cytokines, etc), adaptive immunity (B cells, CD4, CD8 T cells, etc.), systems immunology, translational IO, data science, etc. The PIIO is supported by our Immune Monitoring and Discovery Platform (IMDP), which provides comprehensive cell-based and molecule-based immunoassay services to support basic, translational, and clinical IO studies. The PIIO’s Immuno-Oncology Informatics Group (IOIG) provides data analytics for flow cytometry, bulk and single-cell RNA-Seq, spatial transcriptomics and imaging, neoantigen discovery, and more.

Candidates will have access to state-of-the-art laboratory spaces; cutting-edge core research facilities (Spectrum Flow Cytometry, Multiplex Histology, Single Cell Technology, GMP Facility for Cell Therapy, Antibody Engineering Facility, IO Informatics and more).

The Ohio State University Comprehensive Cancer Center-James

The OSUCCC-James is a National Cancer Institute (NCI)-designated comprehensive cancer center, rated “Exceptional,” the highest rating given to cancer centers by the NCI; is one of only a few centers funded by the NCI to conduct phase I, II and III clinical trials on novel anticancer drugs; and includes the third-largest freestanding cancer hospital in the country, a unique Drug Discovery Institute to promote bench to bedside translation, technology transfer and commercialization.

As one of only 54 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies – providing tomorrow’s standard of care today. A Cancer-Free World Begins Here.

The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.

The Ohio State University College of Medicine
The Ohio State University College of Medicine, with more than 5,000 learners, is the only academic medical center in central Ohio. Ranked as the 28th Best Medical School – Research, 40th Best Medical School – Primary Care, and 13th Most Diverse Medical School by U.S. News & World Report, it is known nationwide for curricular innovation, pioneering research, and outstanding patient care at The Ohio State University Wexner Medical Center. With more than 2,600 faculty members, the college comprises 20 clinical departments, eight basic science departments and a School of Health and Rehabilitation Sciences.

The Wexner Medical Center
The Ohio State University Wexner Medical Center consists of The Ohio State University Health System, the College of Medicine, the Health Sciences Library and the Faculty Group Practice. The Ohio State Wexner Medical Center is committed to providing world-class care. At the Ohio State Wexner Medical Center, we're proud to be celebrating our 31st consecutive year ranked in the U.S. News & World Report Best Hospitals list. This year, the Ohio State Wexner Medical Center has 10 nationally ranked specialties out of 15 and two selected as high performing. U.S. News & World Report consistently ranks the Ohio State Wexner Medical Center as the top hospital in Columbus. The Wexner Medical Center is rated as high performing in 14 out of 20 common procedures and conditions, including abdominal aortic aneurysm repair, aortic valve surgery, heart attack, heart bypass surgery and heart failure.

The University

Ohio State is a top-20 public university, and its Ohio State Wexner Medical Center is one of America’s leading academic health centers and recently ranked No. 4 on Forbes’ list of best U.S. employers for diversity. Eligible Ohio State employees receive comprehensive benefits packages, including medical, dental and vision insurance, tuition assistance for employees and their dependents, and state or alternative retirement options with competitive employer contributions.

The Ohio State University’s Shared Values include Excellence and Impact, Diversity and Innovation, Inclusion and Equity, Care and Compassion, and Integrity and Respect. Our university community welcomes differences, encourages open-minded exploration and courageous thinking, and upholds freedom of expression.

Ohio State is a dynamic community where opportunity thrives, and individuals transform themselves and their world. Positions are available in countless fields and specialties. Become a Buckeye and contribute to an incredible legacy that serves to guide our future and shape a better tomorrow.

The Ohio State University is committed to enhancing academic excellence. Recruiting, supporting, and retaining faculty of the highest caliber is a core component of this commitment. The Office of Academic Affairs (OAA) has established Dual Careers and Faculty Relocation (DCFR) to focus on supporting new and prospective faculty and their loved ones. Service offerings include dual careers partner consultations, identifying potential employers and/or employment opportunities, consultation and resources related to relocation, as well as identifying opportunities to engage on campus and in the surrounding community. While employment opportunities are not guaranteed, resources and consultation are provided to support the partners of new and prospective faculty as they are considering or transitioning to The Ohio State University.

In addition to being responsive to dual-career opportunities, we strongly promote work-life balance to support our community members through a suite of institutionalized policies. Ohio State is an NSF ADVANCE institution and a member of the Ohio/Western Pennsylvania/West Virginia Higher Education Recruitment Consortium (HERC).

Located in Ohio’s capital city, Ohio State’s Columbus campus is near the center of a rapidly growing and diverse metropolitan area with a population of over 1.5 million. The area offers a wide range of affordable housing, many cultural and recreational opportunities, excellent schools, and a strong economy based on government as well as service, transportation, and technology industries. Additional information about the Columbus area is available here. Beyond its Columbus campus, Ohio State has four regional campuses including Ohio State Lima, Ohio State Mansfield, Ohio State Marion, and Ohio State Newark, in addition to the College of Food, Agricultural, and Environmental Sciences (CFAES) Wooster Campus, which houses Ohio State ATI.

Equal Opportunity Employer/Veterans/Disability

Final candidates are subject to successful completion of a background check.

Location:Pelotonia Research Center (1040)Position Type:RegularScheduled Hours:40Shift:First ShiftThe Ohio State University believes in diversity in people and ideas. What Ohio State does matters. And how we do it matters. When we are at our best, we make a real difference to people. Our size, breadth, geography, history and standard of excellence position us to drive the future of higher education. We believe that the university should be a place where people can work and learn together in a safe environment, free of violence, harassment, discrimination, exploitation, or intimidation. As such, finalists for any faculty position that carries tenure must sign an authorization and disclosure form, which will allow current or prior employer(s) to share information to the University regarding any findings of employment-related misconduct or disciplinary proceedings against a candidate and/or any pending investigations related to alleged misconduct. Such information shall include findings and pending investigations with respect to sexual harassment, violence, or harassment; research misconduct; financial fraud or misconduct; foreign influence violations, grant misuse or misconduct; and/or any other type of finding or pending investigation relating to a candidate’s employer’s policies and rules governing faculty conduct that may reasonably be expected to affect a candidate’s appointment. If the University becomes aware of any past finding of misconduct or pending investigations that were not disclosed, Ohio State will treat that as a serious omission and reserves the right to rescind an offer or terminate employment.Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

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