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Research Associate II

4 months ago

Houston, United States Houston Methodist Full time

Overview

At Houston Methodist, the Research Associate II position is responsible for conducting advanced laboratory experiments on research projects with minimal supervision. This position provides advanced technical research skills and establishing test methods and procedures under the direction of Department Chairperson or Scientist (Faculty). The Research Associate II position evaluates results of (or response to) process; summarizes data; may provide oversight and guidance to other associates.

The Altamirano lab at Houston Methodist Research Institute offers a Research Associate II position focused on studying molecular mechanisms driving cardiovascular diseases and arrhythmias. Cardiovascular diseases are the leading cause of death worldwide. Despite efforts to treat arrhythmias such as atrial fibrillation or slow down the progression of heart failure, these diseases are on the rise worldwide. Our lab uses a unique multidisciplinary approach to study molecular mechanisms driving cardiac disease. We combine multiple approaches, including small and large animal models, newer technologies, such as engineered heart tissues made of iPSC-derived cardiomyocytes, and clinical research (in collaboration with Dr. Valderrábano). Our lab is funded by two NIH R01s and the Houston Methodist Cornerstone Award.

Please send CV, cover letter, and contact information for 3 references to faltamirano@houstonmethodist.org

 

Our main research areas are:
Project 1: This project (2022-2027) investigates cardiac dysfunction in Autosomal Polycystic Kidney Disease (ADPKD). It challenges the traditional view that cardiac disease in ADPKD arise from renal impairment, proposing instead that heart disease originates in cardiomyocytes and occurs before renal failure. Evidence includes the presence of ventricular dysfunction in ADPKD patients prior to renal failure, even in non-hypertensive cases. The project focuses on mutations in Polycystin-1 (PC1), found in cardiomyocytes of 85% of ADPKD patients. Preliminary data indicates that these mutations disrupt cardiac function, as seen in mouse models showing altered calcium handling and contractility, leading to heart disease independent of kidney failure. This project aims to uncover how PC1 mutations affect cardiac function, in the context of comorbidities such as hypertension and end-stage renal disease.

 

Project 2: This project is co-led by Dr. Valderrábano and Dr. Altamirano (2023 to 2028). It explores the role of the cardiac nervous autonomic system in Atrial Fibrillation (AF), particularly triggered by sleep apnea. The project builds on the discovery that the cardiac autonomic nervous system (CANS) responds to apnea, affecting AF initiation and progression. The study aims to understand CANS's role in human AF, evaluate CANS-targeting therapies in animal models, and investigate molecular mechanisms in bi- and tri-dimensional cultures of hiPSC-derived atrial cardiomyocytes and neurons.

 

Responsibilities

PEOPLE ESSENTIAL FUNCTIONS

  • Assists PI/faculty by monitoring team of Research Assistants and Post Docs 0-2 scientific activities. Provides communication of needs, issues to be addressed, and all important information necessary to ensure scientific success. Facilitates open, professional, communication to achieve mutual understanding. Role models excellent, clear, and professional communication skills to achieve mutual understanding and problem resolution. Contributes to a team-focused work environment that actively helps one another achieve scientific goals.
  • Promotes a positive work environment with the interprofessional care team to achieve optimal department results. Ensures collaboration among all members of the research team by actively communicating and reporting pertinent information as it relates to assigned system(s) in a comprehensive manner. Participates in teamwork by responding positively to requests for assistance.
  • Teaches peers and staff to critically think by verbally expressing rationale for decisions and follows up consistently. Uses peer-to-peer accountability towards improvement of department score for employee engagement.


SERVICE ESSENTIAL FUNCTIONS

  • At PI/Faculty's direction, organizes the workflow, proactively problem solves, anticipates needs, and manages multiple ongoing priorities. Independently handles resolution of complex problems and issues and notifies PI/Faculty of issue and resolution. Serves as escalation support for less experienced staff.
  • Analyzes data for research grants and publications (medium to high complexity). Maintains accurate records of all research and data collection.
  • Completes/performs research and incorporates novel procedures and methods into research experiments as appropriate (medium complexity).


QUALITY/SAFETY ESSENTIAL FUNCTIONS

  • At the direction of the PI/Faculty, writes and maintains regulatory and safety committee applications/protocols.
  • Provides advanced technical research skills and establishes test methods and procedures. Documents procedures and changes to procedure in PI/Faculty's Lab Study Methods manual and Laboratory Notebooks.
  • Establishes and maintains quality control of project operations including establishing appropriate controls and standards for experimental procedures.


FINANCE ESSENTIAL FUNCTIONS

  • Utilizes resources effectively and efficiently, demonstrating responsible financial stewardship. Manages own time effectively and prioritizes work to achieve maximum results in a timely manner.
  • Assists with ensuring orders for supplies are on appropriate grants.


GROWTH/INNOVATION ESSENTIAL FUNCTIONS

  • Participates in publication and grant writing at PI/Faculty direction.
  • Determines specific research project goals and objectives to be attained. Assumes responsibility and oversight for those goals and objectives at the PI/Faculty's direction.
  • Assists with developing skills of lab team (staff and students) in alignment with scientific objectives.
  • Participates in conferences and seminars. Proactively manages own professional development and completes My Development Plan.


This job description is not intended to be all-inclusive; the employee will also perform other reasonably related business/job duties as assigned. Houston Methodist reserves the right to revise job duties and responsibilities as the need arises.

 

Qualifications

EDUCATION

  • Terminal Degree with Six years' post-doctoral experience or Master of Science degree with nine years' research experience


WORK EXPERIENCE

  • Six years' post-doctoral experience with Terminal Degree or nine years' research experience with Master's degree

 

LICENSES AND CERTIFICATIONS - REQUIRED

  • N/A

 

KNOWLEDGE, SKILLS, AND ABILITIES

  • Demonstrates the skills and competencies necessary to safely perform the assigned job, determined through on-going skills, competency assessments, and performance evaluations
  • Sufficient proficiency in speaking, reading, and writing the English language necessary to perform the essential functions of this job, especially with regard to activities impacting patient or employee safety or security
  • Ability to effectively communicate with patients, physicians, family members and co-workers in a manner consistent with a customer service focus and application of positive language principles
  • Exercises independent judgment related to situations of a sensitive, confidential, and scientific nature
  • Ability to initiate and complete tasks with minimal supervision
  • Ability to deal with high volumes and rigid deadlines

 

SUPPLEMENTAL REQUIREMENTS

WORK ATTIRE

  • Uniform No
  • Scrubs Yes
  • Business professional Yes
  • Other (department approved) No

ON-CALL*
*Note that employees may be required to be on-call during emergencies (ie. DIsaster, Severe Weather Events, etc) regardless of selection below.

  • On Call* No

TRAVEL**
**Travel specifications may vary by department**

  • May require travel within the Houston Metropolitan area No
  • May require travel outside Houston Metropolitan area No

 

 

Company Profile

Houston Methodist Research Institute was formed in 2004 to rapidly and efficiently translate discoveries made in the laboratory and the clinic into new diagnostics, therapies, and treatments. The research institute was created to provide the infrastructure and support for these endeavors, and to house the technology and resources needed to make innovative breakthroughs in important areas of human disease. A 540,000 square foot building dedicated to research, the research institute houses over 1,500 staff and trainees, 284 principal investigators and has more than 570 ongoing clinical trials.

 

Equal Employment Opportunity

Houston Methodist is an Equal Opportunity Employer.

Equal employment opportunity is a sound and just concept to which Houston Methodist is firmly bound. Houston Methodist will not engage in discrimination against or harassment of any person employed or seeking employment with Houston Methodist on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, status as a protected veteran or other characteristics protected by law. VEVRAA Federal Contractor – priority referral Protected Veterans requested.