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Senior Principal Scientist
3 months ago
Drug Safety R&D (DSRD) is a global organization that provides input into drug target selection, helps identify promising drug candidates, discovers and develops biomarker and screening assays, and leads the conduct and interpretation of toxicology studies in support of clinical development programs and registration. Within DSRD, General Toxicology executes general and specialized toxicology study strategies to aid in compound selection and enable clinical development across all phases for all therapeutic areas and modalities, derisk and manage issues, and communicate key information to support decision making in the drug development process. The General Toxicology R6 Study Director is responsible for the design, conduct, interpretation, and reporting of exploratory, mechanistic and GLP in vivo toxicology studies, either conducted internally or by managing the conduct of studies externally. This role will also serve as liaison from General Toxicology to therapeutic area leadership teams and/or serve on multidisciplinary project teams.
The successful candidate will be recognized as a strong scientist and subject matter expert who will apply advanced and comprehensive scientific knowledge and prior work experience to design and execute experiments, participate in and/or lead interdepartmental projects, and engage with external professional societies and consortia. This individual will identify, develop, and lead scientific strategies to support group goals and set direction for the group. The candidate is expected to work independently using their own ideas, knowledge, and experience to routinely develop hypotheses and investigate/solve complex problems, promote the use of novel approaches, and apply business acumen and high level of scientific judgement to make decisions and achieve alignment with stakeholder/interdepartmental needs.
ROLE RESPONSIBILITIES
Responsibilities- Study Director
Responsible for overall technical conduct of in vivo toxicology studies, as well as for the overall interpretation of the studies as described in 21 CFR 58.33., while ensuring compliance with applicable SOPs and guidelines, and Animal Use Protocols.Responsible for communicating with Drug Safety Team Leads (DSTL) to understand study design, including variation from standardized protocol outlines.
Decision-making responsibilities include:
Final call on interpretation of study findings including overall study conclusionMajor modification to study design (eg, discontinuation, dose changes, etc.)Handling study deviations and amendmentsResponsible for dose selection in conjunction with the DSTLOther responsibilities may include serving as a portfolio liaison for General Toxicology to Therapeutic Area Leadership Teams, serving as a DSTL, participating in or leading cross-site teams or consortia, acting as Principal Investigator for animal use protocols, developing new models and methods, authoring guidelines, formal or informal mentoring of junior colleagues, and/or data collection systems updates and implementation processes.
Responsibilities Associated with External Studies
Responsible for oversight of all phases of outsourced studies (study enabling, study setup, in-life, and reporting).Responsible for partnering with DSTLs and subject matter experts to ensure study milestones are appropriately timed and meet necessary scientific and regulatory requirements.Responsible for participating in on-site monitoring of study activities at CRO sites and CRO qualifications as needed.Provides input/feedback to General Toxicology Study Management group, Outsourcing Operations, and CRO staff on issue resolution, best practices and opportunities for improving activities and relationships.
BASIC QUALIFICATIONS
PhD in toxicology, pharmacology, or other appropriate discipline with 8 years relevant professional experienceMS with at least 10 years pharmaceutical industry experience in the design, conduct, direction, or monitoring of toxicology studies.
PREFERRED QUALIFICATIONS
Prior pharmaceutical industry experience developing and executing drug safety strategies to advance therapeutic drug candidatesFamiliarity working under GLP regulationsExperience working in or leading multidisciplinary teamsCandidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Responsible for traveling to CRO sites to monitor study activities (up to 15-20% of time). Business travel may occur on weekends/holidays.
Relocation support available
Work Location Assignment:Flexible
The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
